Optimizing information flow in small genetic networks
نویسندگان
چکیده
منابع مشابه
Optimizing information flow in small genetic networks.
In order to survive, reproduce, and (in multicellular organisms) differentiate, cells must control the concentrations of the myriad different proteins that are encoded in the genome. The precision of this control is limited by the inevitable randomness of individual molecular events. Here we explore how cells can maximize their control power in the presence of these physical limits; formally, w...
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We typically think of cells as responding to external signals independently by regulating their gene expression levels, yet they often locally exchange information and coordinate. Can such spatial coupling be of benefit for conveying signals subject to gene regulatory noise? Here we extend our information-theoretic framework for gene regulation to spatially extended systems. As an example, we c...
متن کاملOptimizing information flow in small genetic networks. I
Gašper Tkačik,∗a Aleksandra M. Walczak,†b and William Bialek‡b,c Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, Pennsylvania 19104–6396 Joseph Henry Laboratories of Physics, Lewis–Sigler Institute for Integrative Genomics, and Princeton Center for Theoretical Science, Princeton University, Princeton, New Jersey 08544 Center for Studies in Physics and Biology, The...
متن کاملOptimizing information flow in small genetic networks. III. A self-interacting gene.
Living cells must control the reading out or "expression" of information encoded in their genomes, and this regulation often is mediated by transcription factors--proteins that bind to DNA and either enhance or repress the expression of nearby genes. But the expression of transcription factor proteins is itself regulated, and many transcription factors regulate their own expression in addition ...
متن کاملOptimizing information flow in small genetic networks. II. Feed-forward interactions.
Central to the functioning of a living cell is its ability to control the readout or expression of information encoded in the genome. In many cases, a single transcription factor protein activates or represses the expression of many genes. As the concentration of the transcription factor varies, the target genes thus undergo correlated changes, and this redundancy limits the ability of the cell...
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ژورنال
عنوان ژورنال: Physical Review E
سال: 2009
ISSN: 1539-3755,1550-2376
DOI: 10.1103/physreve.80.031920